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However, published data allows a directional comparison of the most common GI events: Adverse Event Retatrutide (12 mg) Semaglutide 2.4 mg (STEP trials) Tirzepatide 15 mg (SURMOUNT trials) Nausea ~46% ~44% ~31% Diarrhea ~33% ~30% ~23% Vomiting ~22% ~24% ~12% Constipation ~17% ~24% ~12% Important caveat: These numbers come from different trial populations and cannot be directly compared

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J Drug Deliv Sci Technol 65:102775102775 Mahapatra DK, Asati V, Bharti SK (2015) GnRH analogs as modulator of LH and FSH: exploring clinical importance

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