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Together, these modifications reduce IGFBP binding affinity by approximately 100-fold while preserving full agonist activity at the type 1 IGF receptor (IGF-1R), creating a molecule with dramatically enhanced bioavailability in biological systems

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The findings to date are as follows: One RCT found that kids with ADHD who took synbiotics had less ADHD-associated inflammation, in part because the synbiotics increased short-chain fatty acid production 19

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