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Pfizer halted development of its oral GLP-1 danuglipron in 2025 after a trial participant developed liver injury, reflecting safety concerns that require ongoing monitoring with real-world data

Ive used three bottles of it

GLP-1/Exendin-4 induces -cell proliferation via the epidermal growth factor receptor

Whilst the economic cost of obesity is substantial, the personal cost is often greater with an increased risk of multiple medical and mental health complications

Because the review of 48 studies, although comprehensive, looked at a wide and diverse group of people -- from those with conditions such as diabetes and kidney disease, and those with different starting and end points and who took different medications -- the conclusions drawn also highlight its limitations