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8+ Weeks: Long-Term Remodeling Few published BPC-157 studies extend beyond 8 weeks, but the available data and general tissue biology suggest: Tendon and ligament remodeling continues for 36 months post-injury regardless of intervention BPC-157's primary contribution (angiogenesis, growth factor upregulation) is most impactful in the first 48 weeks Continued dosing beyond 8 weeks is not well-studied

Proteins (20 g) were electrophoresed on 10% SDS-PAGE gels (TGX FastCast 10%, Acrylamide Kit

Additionally, key genes involved in decidualization including FOXO1, NOTCH1, NANOG, WNT4, KLF4, OCT4, SOX2, and LIN28A, as well as angiogenesis-related genes such as HIF1A, VEGFR-2, and VEGFR-3, were significantly upregulated

doi: 10.1016/j.neuroscience.2012.10.057 152 SkupioUWelteJSerratREraso-PichotAJulio-KalajzicFGisquetDet al