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In STZ-treatment rats, Exendin-4 improved learning and memory performance, protected hippocampal neurons against degeneration, and reversed STZ-induced tau hyperphosphorylation through downregulation of GSK-3 activity (154, 155, 182)

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Bergan JJ, Schmid-Schonbein GW, Smith PD, Nicolaides AN, Boisseau MR, Eklof B

If there was a significant interaction, least squares (LS) mean differences were computed and compared using t -tests for the interaction term and main effects forming the term (i.e., challenge material and symptom severity category)

In fact, one of the patients in the phase 2 study for BED died because of toxicology findings consistent with a methamphetamine overdose. So clearly this concern deserves close scrutiny