AP 1903 - CAS# 195514-63-7 Acetyltransferase Inhibitor II 1586/17476348

1586/17476348

InChi: InChI=1S/C27H29FN2O3/c28-25-18-22(13-11-20(25)12-14-27(31)32)29-19-21-6-4-10-26-24(21)9-5-15-30(26)16-17-33-23-7-2-1-3-8-23/h1-4

6 nM toward recombinant human ROCK1

9(6):374-82

GW501516 causes impaired bone formation

AP 1903 - CAS# 195514-63-7 Acetyltransferase Inhibitor II 1586/17476348AP 1903, CAS No. 195514 63 7, also known as Rimiducid, is a lipid permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild type FKBP12 with 1000 fold lower affinity. This agent is used to homodimerize the Fv containing drug binding domains of genetically engineered receptors such as the iCD40