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For example, some clinical trials have shown that oral supplementation and topical applications can lead to noticeable improvements in skin tone and reduction in melanin levels

Our work herein identifies a key role for MC-derived histamine release and subsequent H4R activation in driving clinical and histopathologic severity in UC-like inflammation by regulating innate neutrophil recruitment and associated mucosal injury, likely via coordinating the downstream local production of IL-6 and neutrophil-attracting chemokines

Researchers note that intranasal delivery may especially increase the bioavailability of peptide therapeutics and present an appealing alternative to injection [14, 15, 16]

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