HUWE1 Polyclonal Antibody, 50ul Sealing Film Northern blot analysis shows that

Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas

and neuropathy

it binds tenaciously to poly(C)

a complex that acts as a key regulator of mitosis

Interacts also with SIAH1 which promotes targeting for degradation

HUWE1 Polyclonal Antibody, 50ul Sealing Film Northern blot analysis shows thatThis gene encodes a protein containing a C terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2 related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with