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These inflammatory cytokines can activate multiple signaling pathways, including the nuclear factor (NF)-B, Janus activated kinase/signal transducer and activator of transcription (JAK/STAT), and p38 mitogen-activated protein kinase (MAPK) pathways

Erratum in: Microbiome

doi: 10.1186/s40478-024-01864-2 147 BowlesNPHillMNBhagatSMKaratsoreosINHillardCJMcEwenBS

It is a multi-receptor agonist targeting three key hormone systems that regulate appetite, glucose metabolism, and energy expenditure

10,36 Single-cell RNA sequencing of kidney biopsies from T2D DKD patients revealed a 1240-gene signature associated with hyperfiltration, highlighting endothelial stress and interactions between endothelial and mesangial cells