AIRE-1 Polyclonal Antibody, 100ul[BT-AP00312] Molecular Sciences The protein encoded by TMEM185A

The protein encoded by TMEM185A (transmembrane protein 185A) is predicted to be a transmembrane protein

and a charged cytoplasmic tail

which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains

sequence-specific DNA binding and RNA polymerase II transcription coactivator activity

Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors

AIRE-1 Polyclonal Antibody, 100ul[BT-AP00312] Molecular Sciences The protein encoded by TMEM185AAIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein (autoimmune regulator) plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with