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In early studies more than 50 years ago, increased amounts of phospholipid, cholesterol, and neutral lipids were described, but synovial fluid lipid levels were not predictive of severity of synovitis, questioning a direct involvement of lipids in driving arthritis (120, 121)

Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH: Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells

The story introduces the recurring character Bianca Castafiore, and introduced the fictional countries of Syldavia and Borduria, both of which reappear in later stories

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Elizabeth Bahar Houshmand, a double board-certified dermatologist in Dallas, Texas