ERK 8(Phospho Thr175/Y177) Polyclonal Antibody, 50ul Bio-Reaction Tube two of which encode structurally

two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase

Increases p53/TP53-dependent transcription and apoptosis

Translocated to the nucleus on Ser-151 dephosphorylation

Similar to STAM| this protein acts downstream of JAK kinases| and is phosphorylated in response to cytokine stimulation

The protein is weakly similar to transposase-like proteins in human and mouse

ERK 8(Phospho Thr175/Y177) Polyclonal Antibody, 50ul Bio-Reaction Tube two of which encode structurallyCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,The N terminal region (1 20) is the minimal region necessary for ubiquitination and further proteosomal degradation.,The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1.,In vitro, phosphorylates MBP.,PTM: