SAE1 Polyclonal Antibody, 100ul Metabolic enzymes This protein resembles yeast Prp16

This protein resembles yeast Prp16 more closely than other DEAD/H family members

cofactor:Binds 2 cobalt ions per subunit

The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways

and may play a role in regulating the actin cytoskeleton

Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30)

SAE1 Polyclonal Antibody, 100ul Metabolic enzymes This protein resembles yeast Prp16Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO activating enzyme for the sumoylation of proteins.