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Two transcript variants encoding two different isoforms have been found for PFKFB2

and the C-terminal domain has IMP cyclohydrolase activity

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein

While this locus itself is conserved among various species| the paralogs are found only in the genus Homo| and not in the genomes of non-human great apes

Cyclin D3 Monoclonal Antibody, 100ul Filtration Unleash your potential and takeThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or