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reduce high GI carbs late at night Moderate dose to 1020 mg/day Consider cycling 1216 weeks on, 4 weeks off Prolonged IGF-1 elevation may reduce peripheral insulin sensitivity, though the effect is reversible and dose-dependent. Yuen et al., Hormone and Metabolic Research 5

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The treatment protocols consisted of LC administered at a dose of 2 g/day and LAC at 1 g/day, with intervention durations spanning 12 to 24 weeks across the included trials

Alternative multi-agonists for obesity treatment GLP-1R/GcgR dual agonists have shown impressive metabolic benefits and inspired the search for what now represents a growing class of rationally designed multi-agonists with differentiated mechanisms of action for obesity therapy