TCAL8 Polyclonal Antibody, 20ul Custom DNA Oligos INTS2 (integrator complex subunit 2)

INTS2 (integrator complex subunit 2) is a subunit of the Integrator complex

It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death

It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins

This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene

Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS)

TCAL8 Polyclonal Antibody, 20ul Custom DNA Oligos INTS2 (integrator complex subunit 2)This gene encodes a member of the transcription elongation factor A (SII) like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.