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Cytokines and chemokines secreted by leukocytes, such as tumor necrosis factor, IL-6, and granulocyte colony-stimulating factors to name a few activate endothelial cells, stimulate neovascularization and leukocyte migration, and cause expansion of synovial fibroblast-like and macrophage-like cells [68]

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Data availability The MS proteomics data have been deposited to the ProteomeXchange Consortium ( via the PRIDE partner repository 69 with the dataset identifiers PXD069175 (siRNA C2C12), PXD069216 (siRNA Panc-01), PXD069192 (siRNA MiaPaCa-2), PXD069174 (IP-MS HeLa), PXD069221 (Panc-01 KO /Panc-01 WT), and PXD069222 (Phosphoproteomics C2C12)