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To put that into perspective, if starting BMI was 32, a 16% reduction would bring it down to 27

In the gastrointestinal tract, GLP-1 delays gastric emptying through vagal activation and effects on smooth muscle, increases beta cell proliferation and survival as well as glucose-dependent insulin secretion, suppresses glucagon secretion, and reduces hepatic fat accumulation through fatty acid oxidation as well as hepatic gluconeogenesis [43]

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The standard titration schedule, based on tirzepatide dosing for weight loss protocols , follows this pattern