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Rb(Phospho Ser788) Polyclonal Antibody, 50ul Liquid Handling &Storage The DHR-2 domain is necessary

SKU: 77743301367

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Rb(Phospho Ser788) Polyclonal Antibody, 50ul Liquid Handling &Storage The DHR-2 domain is necessaryThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

The DHR-2 domain is necessary for the GEF activity

GPR32P1 (G Protein-Coupled Receptor 32

Several transcript variants encoding different isoforms have been found for this gene

and Zellweger syndrome

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Rb(Phospho Ser788) Polyclonal Antibody, 50ul Liquid Handling &Storage The DHR-2 domain is necessaryThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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