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Months 7 through 12: long-term adaptation The second half of the first year is generally smooth from a side effect perspective

The goal is sustainable health improvementnot simply maximum weight lossand this requires a balanced, medically supervised approach to both medication management and nutritional intake

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The SURPASS clinical trial program demonstrated that tirzepatide at its highest dose (15 mg weekly) produced average weight loss of 20-25% of body weight, significantly exceeding the results seen with GLP-1 only agonists