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Phospho-ACK (Y284) Polyclonal Antibody, 100ul Liquid Handling &Storage in humans| loss-of-function may play

SKU: 82425896076

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Phospho-ACK (Y284) Polyclonal Antibody, 100ul Liquid Handling &Storage in humans| loss-of-function may playTNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP bound form and inhibits both the intrinsic and GTPase activating protein (GAP) stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C terminal to an SH3 domain. The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP bound active form of Cdc42Hs and which is directly linked to a tyrosine

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Description

in humans| loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors

Mutations in this gene have been associated with congenital insensitivity to pain| anhidrosis| self-mutilating behavior| mental retardation and cancer

predominantly in the basket terminal ring area

The protein encoded by CD99 is a cell surface glycoprotein involved in leukocyte migration

a protein involved in the initiation of DNA replication

Phospho-ACK (Y284) Polyclonal Antibody, 100ul Liquid Handling &Storage in humans| loss-of-function may playTNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP bound form and inhibits both the intrinsic and GTPase activating protein (GAP) stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C terminal to an SH3 domain. The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP bound active form of Cdc42Hs and which is directly linked to a tyrosine

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