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Specifically, vildagliptin forms a transient imidate intermediate with DPP4, stabilized by interactions with Tyr547 and Tyr631 in the S1 subsite

Quick Answer: Dulaglutide and once-weekly exenatide appear to have the lowest rates of nausea amongst GLP-1 receptor agonists, with approximately 1224% of patients affected compared with higher rates seen with other formulations