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If your blood levels of growth hormone are too high by virtue of injecting growth hormone, well then the pituitary can register that and the brain can register that, and then there's a negative feedback that shuts down growth hormone

[DOI] [PubMed] [Google Scholar] Cheng J, Kane LP (2013) Global identification of genes and pathways regulated by Akt during activation of T helper cells

The most clinically relevant efficacy data came from METAOD005, a 12-week randomized double-blind placebo-controlled study

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[1] The FDA prescribing information does not specify a required washout period before conception, so women should consult with their healthcare provider about appropriate timing