ERI1 Polyclonal Antibody, 50ul Fluorescent Staining Accumulation of EXPAND1/MUM1 at damaged

Accumulation of EXPAND1/MUM1 at damaged DNA sites is thought to modify the structure of the chromatin and allow access to other DNA repair factors

centronuclear

and may also mediate protein-protein interactions

It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases

One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity

ERI1 Polyclonal Antibody, 50ul Fluorescent Staining Accumulation of EXPAND1/MUM1 at damagedERI1, also named as HEXO, 3'HEXO and THEX1, contains one exonuclease domain and one SAP domain. The SAP domain is necessary for binding to the stem loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3' end histone mRNA exonuclease activity. It is a RNA exonuclease that binds to the 3' end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. It is