TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Imprinting defects at chromosome 11p13

Imprinting defects at chromosome 11p13 may contribute to tumorigenesis

growth control

namely the Shaw subfamily

Phosphorylation promotes association of TFEB with 14-3-3 family proteins and retention in the cytosol

It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Imprinting defects at chromosome 11p13Catalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only