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Accordingly, composite indices and multi-parametric death-related signatures discussed in this review, including the Cell Death Index (CDI) and Death Vulnerability Signature (DVS), should be interpreted as conceptual or hypothesis-generating frameworks unless supported by independent clinical validation

27 Several, non-enzymatic cofactors like TAFs, mediators, and numerous enzymatic cofactors like the histone-modifying cofactors (histone deacetylase, histone acetyltransferase, histone methyltransferase, histone demethylase) and ATP-dependent chromatin-remodeling cofactors (SWI/SNF, ISWI, Mi-2/NuRD, and INO80/SWR1 families) have been discovered since

Its pleiotropic pharmacological properties particularly anti-inflammatory, antioxidant, and hormonal regulatory effects render it beneficial in the management of various gynecological disorders, including PCOS, PMS, dysmenorrhea, and gynecologic malignancies

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