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MHRA advises restricted use Loperamide for diarrhoea management when appropriate, but should be avoided if blood in stools, fever, or suspected inflammatory/infectious diarrhoea Laxatives for constipation, with macrogol (polyethylene glycol) preparations typically first-line in UK practice, alongside optimising dietary fibre and hydration Dose adjustment strategies include temporarily maintaining a lower dose if gastrointestinal side effects are problematic, allowing additional time for adaptation before escalation

Two entirely separate physiological processes

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Methods The published and validated PRIME Type 2 Diabetes Model was used to project clinical and cost outcomes over patient lifetimes