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Unlike currently approved GLP-1 receptor agonists or dual agonists, Retatrutide simultaneously activates three distinct metabolic pathways

Instead, in a study of 24 adolescents, PWS compared to 72 non-PWS subjects matched for age, gender and BMI, all underwent a laparoscopic SG, a reduction in BMI of 15 kg/m 2 at 1 year and 11 kg/m 2 at 5 years, respectively, was observed, no different than the non-PWS group, in the absence of re-hospitalization for complications during follow-up, suggesting that SG could be an effective and relatively low-risk procedure in these subjects [102]

Second, we only assessed the representative drivers secreted by microglia to astrocytes, whereas we may have overlooked some other microglial cytokines affected by the GLP-1R agonist

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Together, these two may serve as primary pro-ferroptotic drivers