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Ann Surg Oncol 20(6):1934-40, 2013

The different effects of salicylic acid (SA), jasmonic acid (JA), abscisic acid (ABA), and auxin on the expression of the genes indicate that the AtGPX family is regulated by multiple signaling pathways

The IGF-1 Receptor and PI3K/Akt/mTOR Pathway When IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R) on a target cell, it activates a signaling cascade beginning with PI3K, which in turn activates Akt, ultimately converging on mTOR a master regulator of cell growth and protein synthesis

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Studies conducted in mouse models of DMD have suggested that Receptor Grade IGF-1 LR3 and other IGF-1 derivatives may overcome the adverse impacts of Myostatin to protect muscle cells and prevent apoptosis