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Literature References: How May GIP Enhance the Therapeutic Efficacy of GLP-1

The Phase 2 VISTA trial demonstrated that Elecoglipron (AZD5004), a once-daily oral small-molecule GLP-1 receptor agonist, achieved up to 11.8% mean weight loss at 36 weeks in adults with obesity or overweight without diabetes

Mechanistically, P4HA1 enhances glycolytic activity in endothelial cells by down regulating fructose-1, 6-bisphosphatase 1 (FBP1), a negative regulator of glycolysis

As per the NFHS-5 data, 23% of women and 22.1% of men are overweight as per the BMI criterion

The study demonstrates that the uptake and toxicity of polystyrene microplastics (PS-MPs) in a bloodbrain barrier (BBB) model are significantly influenced by microplastic size and inflammatory conditions (16)