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doi: 10.3389/fmicb.2025.1661211 Received 08 July 2025 Accepted 17 September 2025 Published 01 October 2025 Volume 16 - 2025 Edited by Osman Sagdic, Yldz Technical University, Trkiye Reviewed by Furkan Ayaz, Biruni University, Trkiye Karolina Zawadzka, Jagiellonian University Medical College, Poland Updates Copyright 2025 Jiang, Yang, Wu, Tao, Chen, Jin, Sun and Weng

Additionally, Lorcaserin has been found to rely on preproglucagon (PPG) neurons in the NTS (PPG NTS ) to mediate its therapeutic effects on reducing food intake as demonstrated by the lack of response in mice in which PPG NTS neurons are ablated [136]

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Diabetes Care 28(5):10921100 DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L (2008) Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study