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However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing

Dujardin JP, Stone DN

The negative effects of DHA accumulation on the growth of neurites in neurospheres have been linked to the redox imbalance that favors an increase in reactive oxygen species (ROS) production, inducing an irreversible process of protein oxidation, including the carbonylation of cytoskeletal proteins such as actin and tubulin, thus inhibiting the maintenance of neurites (Espinoza et al., 2020)

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Mumuni MA, Kenechukwu FC, Ofokansi KC et al (2020) Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment