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Quick Answer: Significant weight loss alone, regardless of mechanism, can restore ovulation and menstruation in women with obesity-related anovulation In obesity, this extra estrogen contributes to anovulation, irregular cycles, and increased endometrial growth

doi: 10.1016/j.nlm.2010.02.002 56 BenedictCHallschmidMHatkeASchultesBFehmHLBornJet al

2021;4:e00218

Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway

Although reported AEs are generally not serious and safety and efficacy in older adults are generally comparable to those in younger adults [36], higher AE rates may nonetheless predispose older adults to additional risks that are more critical in this population, such as hypoglycemia, dehydration, or impaired renal function