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NMS-P715 (analog) - CAS# 1202055-34-2 cin sulfate Chemical Name: N-(3-methyl-5-sulfamoyl-2

NMS-P715 (analog) - CAS# 1202055-34-2 cin sulfate Chemical Name: N-(3-methyl-5-sulfamoyl-2

Name: NMS-P715 (analog) - CAS# 1202055-34-2 cin sulfate Chemical Name: N-(3-methyl-5-sulfamoyl-2
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NMS-P715 (analog) - CAS# 1202055-34-2 cin sulfate Chemical Name: N-(3-methyl-5-sulfamoyl-2NMS P715 is a selective and orally bioavailable MPS1 inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer

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Chemical Name: N-(3-methyl-5-sulfamoyl-2

Epub 2017 Apr 9

colorectal cancer cells in a concentration-dependent manner

The cell-killing effect on human colon cancer HCT116 cells is found to be time-dependent

therefore GSK-J4 was developed as a pro-drug

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