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Cangui-Panchi SP, acato-Toapanta AL, Enrquez-Martnez LJ, Salinas-Delgado GA, Reyes J, Garzon-Chavez D

By inhibiting the production of isoprenoids from the mevalonate pathway, statins prevent the activation of the ras homolog gene family, member A (RhoA)/rho-associated protein kinase (ROCK) in renal macrophages, thereby reducing the assembly of the NLRP3 inflammasome and subsequent production of IL-1/IL-18 (121, 122)

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