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By consolidating mechanistic insight, clinical validation, safety profiling, pharmacokinetic challenges, and translational strategies into a unified model, this manuscript aims to provide an evidence-based and clinically actionable framework that extends beyond prior narrative summaries

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Interestingly, treatment with forskolin at a low concentration (0.1 M) tended to inhibit MG-induced MMP reduction and apoptosis, while high concentration (10 M) of forskolin substantially inhibited these effects ( Figures 2C, D , respectively), pointing that higher cAMP level confers the protection of mitochondria and prevention of apoptosis induced by MG