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Changes in HRQoL Based on Limitations in Physical Functioning Participants treated with tirzepatide 10 or 15 mg reporting limitations in physical functioning at baseline showed numerically greater mean change from baseline in all SF-36v2 and IWQOL-Lite-CT domains and the EQ-5D-5L Health State Index (UK) and EQ VAS scores, at week 72, compared with those without limitations at baseline (Table 2)