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AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8

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AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8Iodopravadoline, also known as AM630, is an inverse agonist at the human cannabinoid CB1 receptor. Iodopravadoline has been found to attenuate the ability of a number of cannabinoids to inhibit electrically evoked twitches of the mouse isolated vas deferens. AM630 was markedly more potent as an antagonist of delta 9 THC and CP 55,940 (Kd = 14. 0 and 17. 3 nM respectively) than as an antagonist of WIN 55,212 2, AM356 or anandamide (Kd = 36. 5, 85. 9

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Description

84(1):52-8

1-diyl)diphosphonic acid hydrate

and a preference for sphingosines over ihydrosphingosines

Pergolide mesylate is a long-acting dopamine agonist which has been used to treat Parkinson disease and hyperprolactinemia but withdrawn from some markets due to potential for heart valve diseases

the liver is the target organ in each of the three species investigated

AM630 - CAS# 164178-33-0 Catalog No.:M10110-2 84(1):52-8Iodopravadoline, also known as AM630, is an inverse agonist at the human cannabinoid CB1 receptor. Iodopravadoline has been found to attenuate the ability of a number of cannabinoids to inhibit electrically evoked twitches of the mouse isolated vas deferens. AM630 was markedly more potent as an antagonist of delta 9 THC and CP 55,940 (Kd = 14. 0 and 17. 3 nM respectively) than as an antagonist of WIN 55,212 2, AM356 or anandamide (Kd = 36. 5, 85. 9

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