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12 , a033993 (2020)

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Li-mei Yu, [email protected] These authors have contributed equally to this work This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Glutathione pool at an elevated level serves to detoxify the damaging effects of increasing ROS, and therefore, is crucial for the adaptation of cancer cells to oxidative stress for optimal survival and growth 16,17