LY2109761 - TGFβ Inhibitor. CAS# 700874-71-1 size:Contact [email protected] for quotation Pedranzini L

Pedranzini L

LSD1-C76 serves as a very useful chemical probe to study the target biology

ADX-47273 increased (9-fold) the response to threshold concentration of glutamate (50 nM) in fluorometric Ca(2+) assays (EC(50) = 170 nM) in human embryonic kidney 293 cells expressing rat mGlu5

CXCL1 concentration in the serum peaking at 3 h after the injection

oral administration

LY2109761 - TGFβ Inhibitor. CAS# 700874-71-1 size:Contact [email protected] for quotation Pedranzini LLY2109761, CAS No. 700874 71 1, is a highly potent and selective TGF receptor type I and type II (TRI II) inhibitor with Ki of 38 nM and 300 nM respectively. Blocking TRI II kinase activity with LY2109761 completely suppresses both the basal and TGF 1 stimulated migration and invasion of L3. 6pl GLT cells, and completely suppresses TGF induced Smad2 phosphorylation. LY2109761 treatment at 1 nM is sufficient to significantly block the migration and