TIC10 Catalog No.:M8469-10 Pexidartinib hydrochloride (1 mg/kg

Pexidartinib hydrochloride (1 mg/kg

[2H]C([2H])([2H])N1C2=CC=CC=C2C2C(=O)N(CC3N=CNC=3C)CCC1=2

CAS Number: 819812-04-9

Oxid Med Cell Longev

KU-60019 effectively radiosensitizes human glioma cells with dose-enhancement ratio of 1

TIC10 Catalog No.:M8469-10 Pexidartinib hydrochloride (1 mg/kgONC 201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53 independent manner and crosses the blood brain barrier. TIC10 induces a sustained up regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal regulated kinase (ERK), leading to the translocation