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A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)

Less common side effects included skin tingling and a temporary increase in heart rate during the first 24 weeks of treatment

StarLineArts/istock via getty im Regeneron's GLP-1/GIP obesity drug succeeds in late-stage trial Regeneron's dual GLP-1/GIP obesity shot, licensed from Hansoh Pharma, achieved phase 3 weight-loss results that come close to those of Lilly's Zepbound, but with better GI tolerability

Unless you feel unwell, there is usually no need to have extra blood tests after starting it

K., Le Roux, C