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Similar to our previous RNA-seq analysis, we demonstrate that treatment with GLP-1MK-801 significantly regulates around 150 times the number of hypothalamic transcripts relative to the weight-matched semaglutide-treated group, emphasizing a mode of action for GLP-1MK-801 that involves biological pathways independent of the GLP-1 receptor signalling pathway (Fig

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The MHRA stressed that healthcare professionals should identify the increased risk of aspiration as early as possible before surgery and specifically at pre-assessment clinic before surgery, and remind patients to inform their healthcare teams and anaesthetists if they are on GLP-1 or dual GIP/GLP-1 RAs