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In the proximal tubule, the activation of GLP1-R leads to the onset of the cAMP signaling cascade with phosphorylation of NHE3 (Na + /H + exchanger isotope 3) and reduction of its function

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Acknowledgements The authors acknowledge the use of Mind the Graph ( for the design of the figure in this work

As expected, following the same immunoprecipitation approach as above, we measured a complete loss of serine phosphorylation in response to GLP-1 stimulation in the triple AA mutant compared to the WT receptor (Fig

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