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Next-generation candidates like Novos CagriSema or Amgens MariTide will need to demonstrate meaningful advantages in cardiovascular outcomes, NASH or metabolic disease to command better pricing

35,36 Although some studies report smaller reductions in muscle mass, many scientists argue that these findings should not be ignored due to the high metabolic rate of skeletal muscle which plays an important role in maintaining significant weight loss

Most patients see a significant drop in their A1C levels within three to six months of starting treatment, with many staying adherent after an early response

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