Amphiregulin Polyclonal Antibody, 50ul General Lab Use Studies of the mouse and

Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage

This gene is silenced in tumors by DNA methylation

a circulating inhibitor of the formation of new blood vessels (angiogenesis)

and a C-terminal DNA-binding domain

a bleeding disorder (review by Lopez et al

Amphiregulin Polyclonal Antibody, 50ul General Lab Use Studies of the mouse andThe amphiregulin encoded by AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha). The protein interacts with the EGF TGF alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell