Necrostatin-1 faxine Hydrochloride KU-55933 has a dose-dependent effect

KU-55933 has a dose-dependent effect in inhibiting this ATM-dependent phosphorylation event with an estimated IC50 of 300 nM

7 macrophages by upregulating GPR120 expression

benzenesulfonic acid

InChi: InChI=1S/C18H15NO8S2

ClH/c1-9(2)4(7)8-3(5)6

Necrostatin-1 faxine Hydrochloride KU-55933 has a dose-dependent effectNecrostatin 1 is a potent and selective inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin 1 functions as an allosteric inhibitor of the death domain receptor associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin 1 does not present any perturbation of the Fas TNFR triggered canonical apoptosis cascade. Necrostatin 1 inhibits RIP1