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89 As BH 4 is very susceptible to oxidation, ONOO , resulting from the reaction of NO with superoxide anion, may oxidize BH 4 to the BH 3 radical and, thus, the resulting decrease in endothelial BH 4 can induce eNOS uncoupling

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Glutathione is a ubiquitous protective compound in plants, but the structural and functional details of the proteins that synthesize it, as well as the potential biochemical mechanisms of their regulation, have only begun to be explored

Patients on azathioprine, 6-mercaptopurine, or TNF inhibitors require additional pharmacological interaction screening

Glutathione is the major free radical scavenger in the brain, lower levels of this antioxidant elevate cellular vulnerability to oxidative stress