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The activity of CPLA2 is regulated by intracellular calcium mobilization and phosphorylation by mitogen-activated protein kinases (MAPKs)

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Two molecules of Keap1 form a homodimer through the N-terminal BTB domain, and the C-terminal globular domains, called the DC domains, are positioned apart from each other (Ogura et al., 2010

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At the conclusion of the trial, the primary end-point (new infection, kidney dysfunction, or death between days 3 and 15 after the initiation of treatment) did not differ significantly between the groups (adjusted odds ratio: 0.98