Ku-55933 - CAS# 587871-26-9 l-LSB Important role of the LKB1-AMPK

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

PubMed Central PMCID: PMC3813614

3 nM in a radioactive enzyme assay and is over 100-fold selective for other histone methyltransferases/HMTs

and mammary epithelial cells

InChiKey: RDALZZCKQFLGJP-UHFFFAOYSA-N

Ku-55933 - CAS# 587871-26-9 l-LSB Important role of the LKB1-AMPKKU 55933, CAS No. 587871 26 9, is an ATM inhibitor. KU 55933 blocks the phosphorylation of Akt induced by insulin and insulin like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU 55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU 55933 treatment during